4SPIN LAB - spinning its way into regenerative medicine and tissue engineering

The research conducted by the Department of Composites and Carbon Materials based in Prague, focuses principally on advanced composite materials based on natural and synthetic polymers for use in the regenerative medicine and tissue engineering fields. The group enjoys long-term experience with respect to the research of collagen and calcium phosphates, their isolation, characterization and processing. 4SPIN will help us to optimize the electrospinning processes which we’ve been applying for preparing submicron and nanofibers based on collagen or collagen fibers incorporating various nanoparticles such as bioapatite or calcium phosphates. The combination of electrospinning and electroblowing, which 4SPIN allows, can help us to preserve the typical and advantageous unique biological properties of collagen and imitate the major part of extracellular matrix.

Electrospinning offers many unique advantages, such as high surface volume ratio, adjustable porosity, and flexibility to spin various shapes and sizes. Electrospinning of natural and water-soluble polymers it is relatively difficult compared to spinning synthetic polymers due to their high molecular weight, viscosity, rigid chain conformation, etc. It is clear that in many cases the methods of collagen preparation represent a compromise between the degree of disruption/modification of the structure of collagen (mostly at the quaternary level) and the maximum conservation of the biological functions of the collagen biomaterial.

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The potential application of our present research would be osteo-inductive resorbable biomimetic layer allowing the controlled elution of antibiotics to be used as a bone/implant bioactive interface articularly in the case of prosthetic joint infections, or as a preventative procedure with respect to primary joint replacement at a potentially infected site. Further field for potential application would be in bone tissue engineering, namely nanocomposite scaffolds to be used as a bone grafting material.

The Department of Composites and Carbon Materials found that the 4SPIN Lab was the most ideal electrospinning device on the market for our needs, the build quality, comprehensive installation, training and delivery of the 4SPIN LAB has made us very happy customers indeed and proud to be associated with Contipro, 4SPIN and their excellent technology.

For information:

 https://www.4spin.info

 https://www.irsm.cas.cz/index_en.php

 https://www.irsm.cas.cz/materialy/oddeleni/5/propagacni_brozura/USMH_CCM_brozuraA3_2015_tisk.pdf

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